Amphotericin B

Effect of ECMO Deoxycholate: Minimal CS.
Liposomal: Conflicting data.
Dose recommendation Deoxycholate: Use standard dosing.
Liposomal: Consider dosing increase (5-8 mg/kg q24h or higher).
Comments, reference 2x the standard dose of liposomal required in one case report (Pharmacotherapy 2020;40:89). Consider changing liposomal to deoxycholate (Clin Pharmacokinet 2023;62:931). See also: Crit Care 2024;28:326.
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