Imipenem-cilastatin
| Effect of ECMO | Minimal impact on drug PK |
|---|---|
| Dose recommendation | ECMO-specific dose adjustment not required |
| Comments, reference | Use non-ECMO ICU dosing strategies. Prolonged infusion (with therapeutic drug monitoring, if available) suggested for patients with augmented renal clearance (CrCl >130). Ref: Clin Pharmacokinet 2026;65:193. |