Effect of ECMO	Minimal impact on drug PK
Dose recommendation	ECMO-specific dose adjustment not required
Comments, reference	Dosing should be guided mainly by renal function. Higher doses (such as 2 gm q8h via extended infusion) may be necessary for less susceptible pathogens or if aiming for aggressive PK/PD targets. Therapeutic drug monitoring (if available) recommended for patients with augmented renal clearance (CrCl >130) or receiving CRRT. Ref: Clin Pharmacokinet 2026;65:193.