Voriconazole

Effect of ECMO Moderate to heavy CS
Dose recommendation Increase loading dose duration. Start at 6 mg/kg IV q12h x2 days (or after oxygenator change) and then reduce dose to 3-4 mg/kg q24h.
Comments, reference Extensive intersubject and intrasubject variability. Therapeutic drug monitoring strongly encouraged (Crit Care 2024;28:326; Clin Pharmacokinet 2023;62:931).
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