Cách dùng	Thông thường
Liều dùng	1-2 gm IM/IV q12h
Phác đồ liều khác
Thông tin bổ sung	Nhiễm trùng đe dọa tính mạng: tối đa 3 gm q12h

Dose (Age >28 Days)	60-100 mg/kg/day (div q12h)
Max/Day	6 gm

Half-life bình thường	3–4.6
Half-life ESRD	12–30
Liều bình thường	1–2 gm IV q12h
Chỉnh liều suy thận	CrCl >30: No dosage adjustment CrCl 10–30: 1–2 gm q24h CrCl <10: 1–2 gm q48h
Hemodialysis	1–2 gm q24h (+ extra 1 gm AD)
CAPD	1 gm q24h
CRRT	1–2 gm q24h
SLED	No data

Mild impairment (Child-Pugh Class A)	Không chỉnh liều
Moderate impairment (Child-Pugh Class B)	Không chỉnh liều
Severe impairment (Child-Pugh Class C)	Không chỉnh liều

Recommendation	Comments
No dose adjustment appears necessary	In a small retrospective study, there was no difference in surgical site infection rates between 2 gm and 3 gm prophylaxis doses in patients weighing ≥120 kg with median BMI 42 kg/m² (Surg infect 2018;19:504).
No dose adjustment appears necessary	In a small retrospective study, there was no difference in surgical site infection rates between 2 g and 3 g prophylaxis doses in patients weighing >120 kg with median BMI 42 kg/m² (Surg infect 2018;19:504).