Giới thiệu

Cefoxitin là một cephamycin cephalosporin thế hệ 2 dùng đường tiêm.
Đã ghi nhận tình trạng tăng đề kháng của trực khuẩn gram âm kỵ khí, ví dụ Bacteroides sp.
In vitro có thể cảm ứng tăng beta-lactamase, đặc biệt ở Enterobacter sp.
Đối với tác dụng bất lợi chung của nhóm và các thông tin khác, xem Cephalosporins, Overview.

Liều cho người lớn

Cách dùng	Thông thường
Liều dùng	2 gm IV q6-8h
Phác đồ liều khác
Thông tin bổ sung

Liều cho trẻ em

Dose (Age >28 Days)	80-160 mg/kg/day (div q6-8h)
Max/Day	-

Chỉnh liều trên bệnh nhân suy gan

Mild impairment (Child-Pugh Class A)	Không chỉnh liều
Moderate impairment (Child-Pugh Class B)	Không chỉnh liều
Severe impairment (Child-Pugh Class C)	Không chỉnh liều

Chỉnh liều trên bệnh nhân béo phì

Recommendation	Comments
Larger dose possibly required	Insufficient data for a firm recommendation. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).
Larger dose possibly required	Insufficient data for a firm recommendation.. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).

Recommendation

Comments

Larger dose possibly required

Insufficient data for a firm recommendation. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).

Larger dose possibly required

Insufficient data for a firm recommendation.. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).