Usage and Dosing
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Renal Adjustment
| Half-life bình thường | 8–9 |
|---|---|
| Half-life ESRD | 30 |
| Liều bình thường | 6–10 mg/kg IV q24h |
| Chỉnh liều suy thận | CrCl ≥30: No dosage adjustment CrCl <30: 6–10 mg/kg q48h |
| Hemodialysis | 6–10 mg/kg q48h (AD); if next planned dialysis is 72 hrs away, give 9–15 mg/kg26 |
| CAPD | 6–10 mg/kg q48h |
| CRRT | 6–8 mg/kg q24h27 |
| SLED | 6 mg/kg q24h (post-SLED). Consider higher doses (8–12 mg/kg) for severe infection.53 |
Hepatic Adjustment
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ECMO Dosing Adjustment
| Effect of ECMO | Minimal impact on drug PK |
|---|---|
| Dose recommendation | ECMO-specific dose adjustment not required |
| Comments, reference | Dosing should be guided mainly by renal function. Ref: Clin Pharmacokinet 2026;65:193. |
Intraperitoneal Dosing Adjustment, CAPD
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Obesity Dosing Adjustment
| Recommendation | Adjusted BW suggested |
|---|---|
| Comments | Clearance and Vd do not scale proportionally as body wt increases. Therefore, use caution at extremes of weight, even when dosing with adjusted BW (Pharmacotherapy 2023;43:226). Adjusted BW = Ideal BW + 0.4 x (Actual BW – Ideal BW). |
Adverse Effects
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Dược lý
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