Usage and Dosing
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Renal Adjustment
| Half-life bình thường | 2.0 |
|---|---|
| Half-life ESRD | 50 |
| Liều bình thường | Varies with indication |
| Chỉnh liều suy thận | Shown in % of normal daily dose. Loading dose: increase first dose by 100% (max 8 gm). CrCl >40: No dosage adjustment CrCl >30 to 40: 70% (divided q8–12h) CrCl >20 to 30: 60% (divided q8–12h) CrCl >10 to 20: 40% (divided q8–12h) CrCl ≤10: 20% (divided q12–24h) |
| Hemodialysis | 2 gm q48h (give AD) |
| CAPD | No data |
| CRRT | CVVH: No dosage adjustment (based on limited data) |
| SLED | 5 gm q8h; another study recommends 8 gm load, then 5 gm post-SLED.30 |
Hepatic Adjustment
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ECMO Dosing Adjustment
| Effect of ECMO | CS unlikely; no published PK data |
|---|---|
| Dose recommendation | Standard dosing suggested |
| Comments, reference | Ref: Crit Care 2024;28:326. |
Intraperitoneal Dosing Adjustment, CAPD
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Obesity Dosing Adjustment
| Recommendation | Insufficient data |
|---|---|
| Comments | Limited data suggest ↓exposure in obesity. If MIC ≤16 µg/mL, 8 gm IV q8h appears sufficient if CrCl ≤130 mL/min, regardless of obesity status or PK/PD index employed (AAC 2022;66:e0230221; JAC 2019;74:2335). |
Adverse Effects
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Dược lý
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