Usage and Dosing
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Renal Adjustment
| Half-life bình thường | 2.8 |
|---|---|
| Half-life ESRD | Prolonged |
| Liều bình thường | 6 gm IV q8h |
| Chỉnh liều suy thận | CrCl >50: No dosage adjustment CrCl 41–50: 6 gm, then 4 gm q8h CrCl 31–40: 6 gm, then 3 gm q8h CrCl 21–30: 6 gm, then 5 gm q24h CrCl 11–20: 6 gm, then 3 gm q24h |
| Hemodialysis | Dose AD (60–80% removed by HD) |
| CAPD | No data |
| CRRT | No data |
| SLED | No data |
Hepatic Adjustment
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ECMO Dosing Adjustment
| Effect of ECMO | CS unlikely; no published PK data |
|---|---|
| Dose recommendation | Standard dosing suggested |
| Comments, reference | Ref: Crit Care 2024;28:326. |
Intraperitoneal Dosing Adjustment, CAPD
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Obesity Dosing Adjustment
| Recommendation | Insufficient data |
|---|---|
| Comments | Limited data suggest ↓exposure in obesity. If MIC ≤16 µg/mL, 8 gm IV q8h appears sufficient if CrCl ≤130 mL/min, regardless of obesity status or PK/PD index employed (AAC 2022;66:e0230221; JAC 2019;74:2335). |
Adverse Effects
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Dược lý
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