Usage and Dosing
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Renal Adjustment
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Hepatic Adjustment
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ECMO Dosing Adjustment
| Effect of ECMO | Minimal impact on drug PK |
|---|---|
| Dose recommendation | Increased dosing may be required |
| Comments, reference | Standard dosing may not achieve therapeutic targets. Consider 600 mg q8h for severe infection or pathogens with MIC ≥2 µg/mL. Monitor for thrombocytopenia. Ref: Clin Pharmacokinet 2026;65:193. |
Intraperitoneal Dosing Adjustment, CAPD
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Obesity Dosing Adjustment
| Recommendation | Standard dosing may be inadequate |
|---|---|
| Comments | In a PK/PD modeling study in 15 obese patients with MRSA pneumonia (MIC 1-4 µg/mL), standard dosing led to low probability of target attainment in patients age <65 years (J Antimicrob Chemother 2019;74:667). Insufficient concentrations from standard dosing also suggested by PK studies in intraabdominal surgery patients (J Clin Med 2020;9:1067) and critically ill patients with skin and soft tissue infections (Antimicrob Agents Chemother 2021;65:e01619-20). |
Adverse Effects
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Dược lý
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