Usage and Dosing
Không cần chỉnh liều
Renal Adjustment
| Half-life bình thường | 6–14 |
|---|---|
| Half-life ESRD | 7–21 |
| Liều bình thường | 500 mg IV/po q6h |
| Chỉnh liều suy thận | CrCl ≥10: no dosage adjustment CrCl <10: 500 mg q12h |
| Hemodialysis | 500 mg q12h (dose AD) |
| CAPD | No dosage adjustment |
| CRRT | No dosage adjustment |
| SLED | 500 mg q12h (1 dose immediately post-SLED)79 |
Hepatic Adjustment
Không cần chỉnh liều
ECMO Dosing Adjustment
| Effect of ECMO | PK unlikely to be affected by ECMO |
|---|---|
| Dose recommendation | ECMO-specific dose adjustment not required |
| Comments, reference | Ref: Crit Care 2024;28:326. |
Intraperitoneal Dosing Adjustment, CAPD
Không cần chỉnh liều
Obesity Dosing Adjustment
| Recommendation | No dose adjustment appears necessary |
|---|---|
| Comments | Insufficient evidence to support the use of higher doses in obesity (Antimicrob Agents Chemother 2024;68:e0171923). Use actual BW for weight-based dosing, max 4 gm/day. |
Adverse Effects
Không cần chỉnh liều
Dược lý
Không cần chỉnh liều