Usage and Dosing
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Renal Adjustment
| Half-life bình thường | 70–100 |
|---|---|
| Half-life ESRD | up to 230 |
| Liều bình thường | See Adult Dose |
| Chỉnh liều suy thận | If target trough 15–30 µg/mL: Loading dose: eGFR >60: No dosage adjustment eGFR 30–60: Day 1: 12 mg/kg q12h Day 2: 10 mg/kg x1 Day 3: 6–6.7 mg/kg x1 eGFR <30: Day 1: 12 mg/kg q12h Day 2: 5 mg/kg x1 Day 3: 5 mg/kg x1 Maintenance dose: eGFR >60: No dosage adjustment eGFR 30–60: 3–3.3 mg/kg q24h eGFR <30: 5 mg/kg q48h If target trough 20–40 µg/mL: Loading dose: eGFR >60: No dosage adjustment eGFR 30–60: Day 1: 12 mg/kg q12h Day 2: 12 mg/kg x1 Day 3: 12 mg/kg x1 eGFR <30: Day 1: 12 mg/kg q12h Day 2: 12 mg/kg x1 Day 3: 6–6.7 mg/kg x1 Maintenance dose: eGFR >60: No dosage adjustment eGFR 30–60: 5 mg/kg q24h eGFR <30: 3–3.3 mg/kg q24h |
| Hemodialysis | Not removed by HD (use recs for eGFR <30) |
| CAPD | No data |
| CRRT | For CVVHDF: If target trough 15–30 µg/mL: Loading dose: Day 1: 10 mg/kg q12h Day 2: 10 mg/kg x1 Day 3: 10 mg/kg x1 If target trough 20–40 µg/mL: Loading dose: Day 1: 12 mg/kg q12h Day 2: 12 mg/kg x1 Day 3: 12 mg/kg x1 Maintenance dose (both targets): 3–3.3 mg/kg q24h65 |
| SLED | No data |
Hepatic Adjustment
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ECMO Dosing Adjustment
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Intraperitoneal Dosing Adjustment, CAPD
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Obesity Dosing Adjustment
| Recommendation | Use actual BW |
|---|---|
| Comments | Ref: Antimicrob Agents Chemother 2024;68:e0171923. |
Adverse Effects
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Dược lý
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