Amphotericin B
| Recommendation | Use adjusted BW, but consider actual BW if critically ill |
|---|---|
| Comments | Recommendation based on a retrospective analysis evaluating clinical outcomes in 238 patients (Antimicrob Agents Chemother 2021;65:e02366-20). Earlier data from a small PK study support a fixed dose in patients ≥100 kg (e.g., 500 mg for a target dose of 5 mg/kg), which similarly suggests that using actual BW in all obese patients is not the best strategy (Clin Infect Dis 2020;70:2213). |