Cefoxitin

Recommendation	Larger dose possibly required
Comments	Insufficient data for a firm recommendation. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).

Recommendation

Larger dose possibly required

Comments

Insufficient data for a firm recommendation. Single 40 mg/kg perioperative dose in obese patients (based on actual BW; range 4-7.5 gm) resulted in suboptimal achievement of pharmacodynamic targets in both serum and tissue, although performance was better than a simulated 2 gm dose (Antimicrob Agents Chemother 2016;60:5885). A single 4 gm dose administered preop to 200 pts (mean BMI 45.8 kg/m²) failed to reach predefined PK/PD targets for most common pathogens (Antimicrob Agents Chemother 2019;63:e01613-19).

NTTGUIDE

Cefoxitin