Ciprofloxacin

Recommendation	Insufficient data
Comments	Conflicting data regarding effect of obesity on ciprofloxacin plasma PK, suggesting routine dose adjustment not warranted. However, penetration of ciprofloxacin into tissue may be impaired in obesity, resulting in the need for higher doses in difficult-to-access infections. Clinical data required. Refs: Clin Pharmacokinet 2022;61:1167; Pharmacotherapy 2023;43:226; Antimicrob Agents Chemother 2024;68:e0171923.

Recommendation

Insufficient data

Comments

Conflicting data regarding effect of obesity on ciprofloxacin plasma PK, suggesting routine dose adjustment not warranted. However, penetration of ciprofloxacin into tissue may be impaired in obesity, resulting in the need for higher doses in difficult-to-access infections. Clinical data required. Refs: Clin Pharmacokinet 2022;61:1167; Pharmacotherapy 2023;43:226; Antimicrob Agents Chemother 2024;68:e0171923.

NTTGUIDE

Ciprofloxacin