Fluconazole
| Recommendation | Larger dose possibly required |
|---|---|
| Comments | Insufficient data for a firm recommendation. Case reports suggest larger dose required in critically ill obese patients. Recent paper suggests that weight based dosing (12 mg/kg load, then 6 mg/kg/day using total BW) reaches desired PK/PD targets more reliably than fixed dosing; clinical validation required (Pharmacotherapy 17:1023, 1997; Antimicrob Agents Chemother 60:6550, 2016). |