Linezolid

Recommendation	Standard dosing may be inadequate
Comments	In a PK/PD modeling study in 15 obese patients with MRSA pneumonia (MIC 1-4 µg/mL), standard dosing led to low probability of target attainment in patients age <65 years (J Antimicrob Chemother 2019;74:667). Insufficient concentrations from standard dosing also suggested by PK studies in intraabdominal surgery patients (J Clin Med 2020;9:1067) and critically ill patients with skin and soft tissue infections (Antimicrob Agents Chemother 2021;65:e01619-20).

Recommendation

Standard dosing may be inadequate

Comments

In a PK/PD modeling study in 15 obese patients with MRSA pneumonia (MIC 1-4 µg/mL), standard dosing led to low probability of target attainment in patients age <65 years (J Antimicrob Chemother 2019;74:667). Insufficient concentrations from standard dosing also suggested by PK studies in intraabdominal surgery patients (J Clin Med 2020;9:1067) and critically ill patients with skin and soft tissue infections (Antimicrob Agents Chemother 2021;65:e01619-20).

NTTGUIDE

Linezolid