Posaconazole
| Recommendation | Consider increased treatment dose (not prophylaxis) in patients >140 kg |
|---|---|
| Comments | In a PK study, total body weight best predicted changes in drug clearance and Vd. For sufficient exposure, modeling suggests increasing the dose used for treatment to 400 mg IV q24h in patients weighing >140 kg. For prophylaxis, 300 mg IV q24h provides sufficient exposure in patients up to 190 kg. Ref: J Antimicrob Chemother 2020;75:1006. |