Ampicillin-sulbactam

Dose (Age >28 Days)	Per Red Book (2024-2027): (Age >28 days) 150-300 mg/kg/day (divided q6h) Per AMR gram-negative guidance (for CRAB): Neonates: PNA ≤7 days: 450 mg/kg/day (div q8h, 4 hr infusions) PNA 8-60 days: 450 mg/kg/day (div q6h, 4 hrs infusions) Infants and children: 600 mg/kg/day (div q4-6h, 4 hr infusions, max 18 gm/day) Adolescents ≥12 yrs: 9 gm/day sulbactam via 1 of 2 regimens: 9 gm amp/sulb (over 4 hr) q8h, OR 27 gm amp/sulb (continuous infusion)
Max/Day	12 gm (unless otherwise specified)

Dose (Age >28 Days)

Per Red Book (2024-2027):
(Age >28 days)
150-300 mg/kg/day (divided q6h)
Per AMR gram-negative guidance (for CRAB):
Neonates:
PNA ≤7 days: 450 mg/kg/day (div q8h, 4 hr infusions)
PNA 8-60 days: 450 mg/kg/day (div q6h, 4 hrs infusions)
Infants and children:
600 mg/kg/day (div q4-6h, 4 hr infusions, max 18 gm/day)
Adolescents ≥12 yrs:
9 gm/day sulbactam via 1 of 2 regimens:
9 gm amp/sulb (over 4 hr) q8h, OR
27 gm amp/sulb (continuous infusion)

Max/Day

12 gm (unless otherwise specified)