Polymyxin E, Colistin

Netilmicin

PK/PD Index 24-hr AUC/MIC
Pharmaceutical Preparations Injection
Food Rec (PO Drugs) 1 -
Oral Absorption (%) -
Tmax (hr) -
Peak Serum Conc (µg/mL) 2 4-8 (2 mg/kg IV, SD)
Peak Urine Conc (µg/mL) No data
Protein Binding (%) 0-10
Volume of Distribution (Vd) 3 0.26 L/kg
Avg Serum T½ (hr) 4 2-3
Elimination Renal
Bile Penetration (%) 5 10-60
CSF/blood (%) 6 0-30
Therapeutic Levels in CSF 7 No
AUC (µg*hr/mL) 8 No data

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