NTTGUIDE

Amikacin

Half-life bình thường 2-3
Half-life ESRD 30-70
Liều bình thường G- (conventional):
7.5 mg/kg IM/IV q12h
NTM:
10-15 mg/kg IM/IV q24h
Chỉnh liều suy thận G- (conventional):
CrCl >50: No dosage adjustment
CrCl 10-50: 7.5 mg/kg q24h
CrCl <10: 7.5 mg /kg q48h
NTM:
Dosage if ↓GFR poorly defined
Adjust to these targets:
Peak
35-45 µg/mL (15 mg/kg)
65-80 µg/mL (25 mg/kg)
Trough:
<1 µg/mL
Hemodialysis G- (conventional):
7.5 mg/kg q48h
(+ extra 3.75 mg/kg AD)
CAPD For peritonitis only:
2 mg/kg IP once daily
CRRT Extended-interval:
CVVH, CVVHDF:
25 mg/kg q48h
TDM recommend
SLED No data

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