Cefepime
| Half-life bình thường | 2 |
|---|---|
| Half-life ESRD | 18 |
| Liều bình thường | 1–2 gm IV q8–12h |
| Chỉnh liều suy thận | For target dose (NRF) 1–2 gm q12h: CrCl >60: No dosage adjustment CrCl 30–60: 1–2 gm q24h CrCl 11–29: 0.5–1 gm q24h CrCl <11: 0.25–0.5 gm q24h For target dose (NRF) 2 gm q8h: CrCl >60: No dosage adjustment CrCl 30–60: 2 gm q12h CrCl 11–29: 2 gm q24h CrCl <11: 1 gm q24h |
| Hemodialysis | For target dose (NRF) 1–2 gm q12h: 1 gm day 1, then 500 mg q24h For target dose (NRF) 2 gm q8h: 1 gm q24h (AD on dialysis days) Alternative: 2 gm AD (3x/wk HD) |
| CAPD | For target dose (NRF) 1–2 gm q12h: 1–2 gm q48h For target dose (NRF) 2 gm q8h: 2 gm q48h |
| CRRT | Dose per EFR: ≤2 L/hr: 1.5 gm q12h 2.1–3 L/hr: 2 gm q12h 3.1–4 L/hr: 1.5 gm q8h ≥4.1 L/hr: 2 gm q8h |
| SLED | 2 gm load, then 1 gm q6h OR 2 gm pre-, 3 gm post-SLED |