NTTGUIDE

Cefoperazone-sulbactam

Half-life bình thường Cefoperazone 1.7–2.0
Sulbactam 1.0
Half-life ESRD Cefoperazone: No change
Sulbactam: 6.9–9.7
Liều bình thường 2–4 gm/day (divided q12h)
(i.e., cefoperazone 1–2 gm/day)
Chỉnh liều suy thận Adjustment necessary for sulbactam:
CrCl ≥30: No dosage adjustment
CrCl 15–30: Sulbactam 1 gm q12h
CrCl <15: Sulbactam 500 mg q12h
Hemodialysis Sulbactam 500 mg q12h
(AD on dialysis days)
CAPD No data
CRRT Sulbactam 1 gm q8h
SLED No data

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