NTTGUIDE

Ceftolozane-tazobactam

Half-life bình thường Ceftolozane 3.1
Half-life ESRD Ceftolozane 40
Liều bình thường IAI/UTI: 1.5 gm IV q8h
HAP/VAP: 3 gm IV q8h
Chỉnh liều suy thận CrCl >50:
No dosage adjustment
CrCl 30–50:
IAI/UTI: 750 mg q8h
HAP/VAP: 1.5 gm q8h
CrCl 15–29:
IAI/UTI: 375 mg q8h
HAP/VAP: 750 mg q8h
CrCl <15 on HD:
See HD recommendations
Hemodialysis IAI/UTI:
750 mg load, 150 mg q8h
HAP/VAP:
2.25 gm load, 450 mg q8h
CAPD No data
CRRT CVVHDF: 3 gm x1, then 750 mg q8h
SLED No data

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