Famciclovir

Half-life bình thường penciclovir 2-3
Half-life ESRD penciclovir 10-22
Liều bình thường Varies with indication
Chỉnh liều suy thận Recurrent genital herpes:
CrCl ≥60: 1000 mg q12h x1 day
CrCl 40-59: 500 mg q12h x1 day
CrCl 20-39: 500 mg x1 dose
CrCl <20: 250 mg x1 dose
Recurrent herpes labialis:
CrCl ≥60: 1500 mg x1 dose
CrCl 40-59: 750 mg x1 dose
CrCl 20-39: 500 mg x1 dose
CrCl <20: 250 mg x1 dose
Herpes zoster:
CrCl ≥60: 500 mg q8h
CrCl 40-59: 500 mg q12h
CrCl 20-39: 500 mg q24h
CrCl <20: 250 mg q24h
Suppression of recurrent genital herpes:
CrCl ≥40: 250 mg q12h
CrCl 20-39: 125 mg q12h
CrCl <20: 125 mg q24h
Recurrent orolabial/genital herpes (HIV):
CrCl ≥40: 500 mg q12h
CrCl 20-39: 500 mg q24h
CrCl <20: 250 mg q24h
Hemodialysis Recurrent genital herpes:
250 mg x1 dose AD
Recurrent herpes labialis:
250 mg x1 dose AD
Herpes zoster:
250 mg after each dialysis
Suppression of recurrent genital herpes:
125 mg after each dialysis
Recurrent orolabial/genital herpes (HIV)
250 mg after each dialysis
CAPD No data
CRRT No data
SLED No data
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