Fluconazole
| Half-life bình thường | 20-50 |
|---|---|
| Half-life ESRD | 100 |
| Liều bình thường | 100-400 mg IV/po q24h |
| Chỉnh liều suy thận | CrCl >50: No dosage adjustment CrCl ≤50: 50-200 mg q24h |
| Hemodialysis | 50-200 mg q24h on non-dialysis days, 100-400 mg (full dose) AD on dialysis days |
| CAPD | 50-200 mg q24h |
| CRRT | At least 2x usual dose suggested |
| SLED | 800 mg initial dose, then 400 mg q12h (or pre/post SLED). Give initial dose at start of an 8-hr dialysis session, or 16 hours before the next session. |