Imipenem-cilastatin
| Half-life bình thường | 1 |
|---|---|
| Half-life ESRD | 4 |
| Liều bình thường | Variable |
| Chỉnh liều suy thận | If target dose 500 mg q6h: CrCl ≥90: No dosage adjustment CrCl 60 to <90: 400 mg q6h CrCl 30 to <60: 300 mg q6h CrCl 15 to <30: 200 mg q6h If target dose 1 gm q8h: CrCl ≥90: No dosage adjustment CrCl 60 to <90: 500 mg q6h CrCl 30 to <60: 500 mg q8h CrCl 15 to <30: 500 mg q12h If target dose 1 gm q6h: CrCl ≥90: No dosage adjustment CrCl 60 to <90: 750 mg q8h CrCl 30 to <60: 500 mg q6h CrCl 15 to <30: 500 mg q12h |
| Hemodialysis | If target dose 1 gm q6h: 500 mg q12h (dose AD) |
| CAPD | No data |
| CRRT | 0.5-1 gm q6h (varies with MIC, effluent rate) |
| SLED | No data |