Half-life bình thường	Piperacillin: 1 Tazobactam: 1
Half-life ESRD	Piperacillin: 3–5 Tazobactam: 2.8
Liều bình thường	Extended Infusion: 4.5 gm IV (over 4 hr) q8h Intermittent Infusion: Nosocomial pneumonia: 4.5 gm IV (over 30 min) q6h All other indications: 3.375 gm IV (over 30 min) q6h
Chỉnh liều suy thận	Extended Infusion: CrCl ≥20: No dosage adjustment CrCl <20: 4.5 gm (over 4 hr) q12h Intermittent Infusion: Nosocomial pneumonia: CrCl >40: No dosage adjustment CrCl 20–40: 3.375 gm q6h CrCl <20: 2.25 gm q6h All other indications: CrCl >40: No dosage adjustment CrCl 20–40: 2.25 gm q6h CrCl <20: 2.25 gm q8h
Hemodialysis	Extended Infusion: 4.5 gm (over 4 hr) q12h Intermittent Infusion: Nosocomial pneumonia: 2.25 gm q8h (+0.75 gm AD on dialysis days) All other indications: 2.25 gm q12h (+0.75 gm AD on dialysis days)
CAPD	Extended Infusion: No data Intermittent Infusion: Nosocomial pneumonia: 2.25 gm q8h All other indications: 2.25 gm q12h
CRRT	Extended Infusion: 3.375–4.5 gm (over 4 hr) q8h Intermittent Infusion: 3.375–4.5 gm q6h^{42, 47}
SLED	Intermittent Infusion: 4.5 gm q8h May use extended infusion⁵³