Polymyxin E, Colistin
| Half-life bình thường | 6.3-12 |
|---|---|
| Half-life ESRD | ≥48 |
| Liều bình thường | Load: 4 x (wt in kg) Maintenance: 180 mg q12h |
| Chỉnh liều suy thận | CrCl ≥90: 180 mg q12h CrCl 80 to <90: 170 mg q12h CrCl 70 to <80: 150 mg q12h CrCl 60 to <70: 137.5 mg q12h CrCl 50 to <60: 122.5 mg q12h CrCl 40 to <50: 110 mg q12h CrCl 30 to <40: 97.5 mg q12h CrCl 20 to <30: 87.5 mg q12h CrCl 10 to <20: 80 mg q12h CrCl 5 to <10: 72.5 mg q12h CrCl <5: 65 mg q12h |
| Hemodialysis | Non-HD days: give 65 mg IV q12h. HD days: give supplemental dose of 40-50 mg after a 3-4 hr session. Give this supplement with the next regular dose after the dialysis has ended. |
| CAPD | No data |
| CRRT | 220 mg q12h |
| SLED | Add 13 mg per hour of SLED to the baseline dose of 65 mg q12h. Ex: For 10 hr SLED, dose is 130 mg q12h. |