Valacyclovir

Half-life bình thường 3
Half-life ESRD 14
Liều bình thường Varies with indication
Chỉnh liều suy thận Herpes labialis:
CrCl ≥50: 2 gm q12h x2 doses
CrCl 30-49: 1 gm q12h x2 doses
CrCl 10-29: 500 mg q12h x2 doses
CrCl <10: 500 mg x1 dose
Genital herpes, initial episode:
CrCl ≥50: 1 gm q12h
CrCl 30-49: No dosage adjustment
CrCl 10-29: 1 gm q24h
CrCl <10: 500 mg q24h
Genital herpes, recurrent episode:
CrCl ≥50: 500 mg q12h
CrCl 30-49: No dosage adjustment
CrCl 10-29: 500 mg q24h
CrCl <10: 500 mg q24h
Genital herpes, suppression:
CrCl ≥50: 1 gm q24h
CrCl 30-49: No dosage adjustment
CrCl 10-29: 500 mg q24h
CrCl <10: 500 mg q24h
Genital herpes, suppression, HIV-infected:
CrCl ≥50: 500 mg q12h
CrCl 30-49: No dosage adjustment
CrCl 10-29: 500 mg q24h
CrCl <10: 500 mg q24h
Herpes zoster:
CrCl ≥50: 1 gm q8h
CrCl 30-49: 1 gm q12h
CrCl 10-29: 1 gm q24h
CrCl <10: 500 mg q24h
Hemodialysis 500 mg q24h
(AD on dialysis days)
CAPD 500 mg q24h
CRRT No data
SLED No data
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