Half-life bình thường	6
Half-life ESRD	200–250
Liều bình thường	15–20 mg/kg IV q8–12h
Chỉnh liều suy thận	CrCl >100: No dosage adjustment CrCl >50–100: 15–20 mg/kg q12h CrCl 20–50: 15–20 mg/kg q24h CrCl <20: 15–20 mg/kg q48h
Hemodialysis	POST-HD DOSING Low permeability membrane: Load: 25 mg/kg Maintenance: 7.5 mg/kg AD High permeability membrane: Load: 25 mg/kg Maintenance: 10 mg/kg AD INTRADIALYTIC DOSING Low permeability membrane: Load: 30 mg/kg Maintenance: 7.5–10 mg/kg High permeability membrane: Load: 35 mg/kg Maintenance: 10–15 mg/kg
CAPD	7.5 mg/kg q48–96h
CRRT	Load: 20–25 mg/kg Maintenance: 7.5–10 mg/kg q12h (effluent 20–25 mL/kg/hr). TDM suggested.
SLED	Load: 20–25 mg/kg Maintenance: 15 mg/kg AD (or during final 60–90 min of dialysis). TDM suggested.